Rabbit Secondary Antibodies
ABclonal Technology 700 Rabbit anti-Human CD7
This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily This protein is found on thymocytes and mature T cells It plays an essential role in T-cell interactions and also in T-cell B-cell interaction during early lymphoid development
ABclonal Technology 647 Rabbit anti-Human CD1d
This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells The human genome contains five CD1 family genes organized in a cluster on chromosome 1 The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail Two transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 594 Rabbit anti-Human CD9
This gene encodes a member of the transmembrane 4 superfamily also known as the tetraspanin family Tetraspanins are cell surface glycoproteins with four transmembrane domains that form multimeric complexes with other cell surface proteins The encoded protein functions in many cellular processes including differentiation adhesion and signal transduction and expression of this gene plays a critical role in the suppression of cancer cell motility and metastasis
ABclonal Technology 647 Rabbit anti-Human CD99
The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration T-cell adhesion ganglioside GM1 and transmembrane protein transport and T-cell death by a caspase-independent pathway In addition the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation There is a related pseudogene located immediately adjacent to this locus
ABclonal Technology PerCP Rabbit anti-Human CD68
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages It is a member of the lysosomal endosomal-associated membrane glycoprotein (LAMP) family The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins The protein is also a member of the scavenger receptor family Scavenger receptors typically function to clear cellular debris promote phagocytosis and mediate the recruitment and activation of macrophages Alternative splicing results in multiple transcripts encoding different isoforms
ABclonal Technology 488 Rabbit anti-Human CD89
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils monocytes macrophages and eosinophils where it mediates immunologic responses to pathogens It interacts with IgA-opsonized targets and triggers several immunologic defense processes including phagocytosis antibody-dependent cell-mediated cytotoxicity and stimulation of the release of inflammatory mediators Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene
ABclonal Technology APC Rabbit anti-Human CD11a
ITGAL encodes the integrin alpha L chain Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1) which is expressed on all leukocytes LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands ICAMs 1-3 (intercellular adhesion molecules 1 through 3) and also functions in lymphocyte costimulatory signaling Two transcript variants encoding different isoforms have been found for this gene
ABclonal Technology APC Rabbit anti-Human CD1B mAb
This gene encodes a member of the CD1 family of transmembrane glycoproteins which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells The human genome contains five CD1 family genes organized in a cluster on chromosome 1 The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail and requires vesicular acidification to bind lipid antigens
ABclonal Technology 594 Rabbit anti-Human CD34
Enables sulfate binding activity Acts upstream of or within leukocyte migration Located in cytoplasm external side of plasma membrane and extracellular region Is expressed in several structures including alimentary system cardiovascular system extraembryonic component genitourinary system and skin Orthologous to human CD34 (CD34 molecule)
ABclonal Technology 450 Rabbit anti-Human CD99
The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration T-cell adhesion ganglioside GM1 and transmembrane protein transport and T-cell death by a caspase-independent pathway In addition the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation There is a related pseudogene located immediately adjacent to this locus
ABclonal Technology 488 Rabbit anti-Human CD86
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily This protein is expressed by antigen-presenting cells and it is the ligand for two proteins at the cell surface of T cells CD28 antigen and cytotoxic T-lymphocyte-associated protein 4 Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response Alternative splicing results in several transcript variants encoding different isoforms
ABclonal Technology APC Rabbit anti-/Human CD55
This gene encodes an inhibitor of both the classical and the alternative pathways of complement activation The encoded preproprotein undergoes post-translational processing to generate a mature polypeptide anchored to the plasma membrane via a glycosylphosphatidylinositol moiety Erythrocytes from mice deficient in the encoded protein exhibit impaired regulation of complement activation resulting in enhanced complement deposition Mice lacking the encoded protein exhibit enhanced susceptibility to experimentally induced myasthenia gravis This gene is located adjacent to a closely related gene on chromosome 1
ABclonal Technology 488 Rabbit anti-Human CD9
This gene encodes a member of the transmembrane 4 superfamily also known as the tetraspanin family Tetraspanins are cell surface glycoproteins with four transmembrane domains that form multimeric complexes with other cell surface proteins The encoded protein functions in many cellular processes including differentiation adhesion and signal transduction and expression of this gene plays a critical role in the suppression of cancer cell motility and metastasis
ABclonal Technology 488 Rabbit anti-Human CD38
The protein encoded by this gene is a non-lineage-restricted type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5 -diphosphate-ribose an intracellular calcium ion mobilizing messenger The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein This protein has an N-terminal cytoplasmic tail a single membrane-spanning domain and a C-terminal extracellular region with four N-glycosylation sites Crystal structure analysis demonstrates that the functional molecule is a dimer with the central portion containing the catalytic site It is used as a prognostic marker for patients with chronic lymphocytic leukemia Alternative splicing results in multiple transcript variants
ABclonal Technology PE Rabbit anti-Human CD42b mAb
Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer an alpha chain and a beta chain that is linked by disulfide bonds The Gp Ib functions as a receptor for von Willebrand factor (VWF) The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury and also initiates signaling events within the platelet that lead to enhanced platelet activation thrombosis and hemostasis This gene encodes the alpha subunit Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy